Teva Pharmaceuticals Making Waves in Schizophrenia Treatment
Much of the recent excitement in the field of schizophrenia treatment has centered around Bristol Myers Squibb’s Cobenfy, the first newly approved therapy for the condition in decades. However, even with this new option available, patients with schizophrenia still face challenges with side effects and varying levels of efficacy with current medications. Teva Pharmaceuticals sees an opportunity to revolutionize the field by offering next-generation options for existing medications.
In 2023, Teva received FDA approval for its schizophrenia drug Uzedy, which exceeded revenue expectations by bringing in $117 million last year. What sets Uzedy apart is not a new molecule, but rather its innovative method of delivery. Developed using technology licensed from Medincell called SteadyTeq, Uzedy offers a long-acting subcutaneous form of the well-established Johnson & Johnson medication risperidone. This once-monthly, slow-release formulation aims to improve patient adherence to the medication, a significant challenge in schizophrenia treatment.
Heather DeMyers, Vice President of U.S. Innovative Medicines at Teva, emphasized the importance of adherence in schizophrenia treatment, noting that 80% of patients relapse from their medications. Building on the success of Uzedy, Teva is now working on TEV-’749, a subcutaneous long-acting form of the common schizophrenia medication olanzapine. By controlling the release of the medication, TEV-’749 aims to help patients achieve optimal treatment quickly and reduce the risk of relapse.
Teva’s larger plan involves leveraging its CNS pipeline to drive growth across its generics and biosimilars business, operations, branded drugs, and innovative medicines. This strategy, known as the “Pivot to Growth” plan, contributed to a 6% increase in revenue to $16.54 billion last year. In addition to Uzedy, Teva’s innovative medicines portfolio saw success with Austedo, a drug approved for Huntington’s disease and tardive dyskinesias, projected to reach $2.5 billion in revenue by 2027.
Interim late-stage results for TEV-’749 have been promising, with the drug meeting its efficacy endpoint and demonstrating a favorable safety profile in phase 1 studies. Teva and Medincell recently completed the phase 3 trial for TEV-’749, with full results expected later this year. If data from the later-stage studies show a lower incidence of post-injection delirium/sedation syndrome, TEV-’749 could differentiate itself in the market.
Teva is among several companies developing longer-acting schizophrenia medications, aiming to improve treatment outcomes for the approximately 3.5 million Americans living with the condition. The stigma surrounding schizophrenia can often impact diagnosis and medication adherence, making long-acting medications like TEV-’749 a potential game-changer. By offering a subcutaneous technology that reduces the burden of daily medication reminders, Teva is poised to make a significant impact in the field of schizophrenia treatment. The world is constantly changing, and with it, so are the ways in which we interact with one another. From the rise of social media to the increasing reliance on digital communication, the way we communicate is evolving at a rapid pace. In this article, we will explore some of the latest trends in communication and how they are shaping the way we connect with others.
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