DMT, or dimethyltryptamine, is a natural psychoactive molecule that has been making waves in the field of stroke research. A recent study published in Science Advances by researchers from the HUN-REN BRC Institute of Biophysics and Semmelweis University Heart and Vascular Center has shed light on the potential of DMT in reducing the harmful effects of stroke in animal models and cell culture experiments.
The researchers found that DMT, which is also naturally present in the human brain, significantly reduced infarct volume and edema formation in a rat stroke model. This was achieved by restoring the structure and function of the damaged blood-brain barrier and improving the function of astroglial cells. Additionally, DMT treatment inhibited the production of inflammatory cytokines in brain endothelial cells and peripheral immune cells, while also reducing the activation of brain microglia cells through Sigma-1 receptors.
Lead author Mária Deli expressed excitement about the findings, stating, “It is amazing how we can always turn to nature to find ingenious solutions for health problems.” Co-first author Marcell László further emphasized the potential of DMT in stroke treatment, highlighting its dual action of protecting the blood-brain barrier and reducing brain inflammation.
The therapeutic options currently available for stroke are limited, making the discovery of DMT’s effects even more significant. The researchers believe that a DMT-based treatment could complement existing therapies and offer a novel approach to stroke recovery. Clinical trials on the use of DMT and investigations into its long-term effects are currently underway, paving the way for a potentially groundbreaking new treatment option.
The study, titled “N,N-dimethyltryptamine mitigates experimental stroke by stabilizing the blood-brain barrier and reducing neuroinflammation,” provides valuable insights into the potential benefits of DMT in stroke treatment. The researchers from Szeged and Budapest, Hungary, are hopeful that their findings will contribute to the development of innovative therapies that address the limitations of current stroke treatments.
As research on DMT continues to progress, it is clear that this natural compound has the potential to revolutionize stroke care. With its unique mechanism of action and promising results in animal models, DMT could soon become a key player in the fight against stroke-related complications. Stay tuned for more updates on this groundbreaking research as it unfolds.
