Steroid hormone levels in healthy adults are influenced by various factors such as oral contraceptives, smoking, age, sex, genetics, and lifestyle choices, according to a recent study published in the journal Science Advances.
The research aimed to enhance our understanding of steroid hormone levels, including corticoids and sex hormones, in both men and women across different age groups. This study, led by Dr. Darragh Duffy and Dr. Molly Ingersoll from the Institut Pasteur, analyzed a wide range of hormones in nearly 1,000 healthy individuals, providing valuable insights into these essential molecules that impact our overall well-being.
One significant finding from the study was the impact of oral contraceptive use on steroid hormone levels in women, and the association of smoking with altered hormone levels in men. Additionally, the research revealed that changes in specific androgens over a 10-year period were linked to various age-related diseases in men, underscoring the role of these hormones in disease development.
Dr. Jamie Sugrue, one of the co-first authors of the study, highlighted the importance of understanding how hormone variations can affect immune responses. The team plans to further investigate the relationship between hormone levels and immune function to uncover new insights into individual differences in immunity.
Professor Cliona O’Farrelly from Trinity College Dublin emphasized the significance of studying immune system variations on a molecular level, especially in light of the COVID-19 pandemic. Being part of the Milieu Interieur collaboration provides researchers with a unique opportunity to explore the genetic and molecular mechanisms underlying immune diversity at a large scale.
Dr. Léa G Deltourbe, another co-first author, noted that the study contributes valuable data to the growing interest in the role of steroid hormones in health and disease. The findings offer a foundation for investigating the impact of endocrine disruptors, stress-related cortisol levels, and the influence of sex hormones on overall well-being.
Understanding the effects of oral contraceptives on physical and mental health can lead to improved quality of life for women using these medications. By delving deeper into the complex interplay between hormones, lifestyle factors, and genetic influences, researchers hope to pave the way for personalized approaches to healthcare in the future.
For more information on this study, you can access the full article in Science Advances: DOI: 10.1126/sciadv.adu6094. This research was made possible through the collaborative efforts of the Milieu Interieur consortium and Trinity College Dublin, providing valuable insights into the intricate relationship between hormone levels and overall health.
