Hydrogen sulfide, the volcanic gas that smells of rotten eggs, could potentially revolutionize the treatment of nail infections, as suggested by researchers from the University of Bath and King’s College London (KCL).
Nail infections, commonly caused by fungi and occasionally by bacteria, affect a significant portion of the global population. These infections, which can have serious implications for vulnerable groups such as diabetics and the elderly, are notoriously challenging to treat effectively.
Current treatments for nail infections include oral antifungals and topical solutions. Oral antifungals, while reasonably effective, can take several months to show results and may lead to adverse side effects, particularly in individuals with underlying health conditions. On the other hand, topical treatments often take longer to work and have high rates of relapse or failure due to the difficulty of penetrating the nail to reach the infection.
In light of these challenges, the research team from the University of Bath and KCL has identified hydrogen sulfide (H₂S) as a promising alternative treatment for nail infections. Previous studies have demonstrated that H₂S can penetrate the nail plate more efficiently than existing drugs and exhibits potent antimicrobial properties against a broad spectrum of nail pathogens, including drug-resistant fungi.
Laboratory experiments have revealed that H₂S disrupts microbial energy production and induces irreversible damage to the fungi, ultimately leading to their demise. Dr. Albert Bolhuis from the University of Bath emphasized the potential of a topically applied H₂S medication to address the limitations of current therapies and provide a highly effective treatment for persistent fungal nail infections.
While hydrogen sulfide is known for its distinct odor and toxicity, the researchers believe that the required concentrations for therapeutic purposes would be well below toxic levels, and proper formulation could mitigate any unpleasant smells. Although the research is currently limited to laboratory settings, the team aims to develop a topical treatment that could be available to patients within the next five years.
Professor Stuart Jones from KCL expressed enthusiasm about translating these findings into an innovative product for nail infection treatment, highlighting the importance of advancing research in this area. The study, published in Scientific Reports, provides a solid foundation for the development of a new therapeutic approach that could significantly improve outcomes for individuals suffering from fungal nail infections.
