Amniotic fluid is a crucial substance that surrounds and protects a fetus during pregnancy. Despite its importance, this fluid has not been extensively studied due to the challenges of obtaining it throughout gestation. However, researchers at Oregon Health & Science University (OHSU) have recently made significant discoveries regarding the properties and potential uses of amniotic fluid.
A recent study published in the journal Research and Practice in Thrombosis and Haemostasis revealed that the addition of amniotic fluid to plasma, the liquid portion of blood, enhances the blood’s ability to clot. This finding is particularly important during pregnancy and delivery, as proper blood clotting is essential for the health and safety of both the birthing parent and the baby.
Led by Dr. Jamie Lo, a multidisciplinary team of OHSU researchers explored how the composition of amniotic fluid changes over the course of pregnancy. They found that the proteins and fatty acids present in the fluid evolve to meet the growing needs of the developing fetus. This discovery led the team to investigate the potential protective factors of amniotic fluid and consider its regenerative and therapeutic uses.
Collaborating with experts in the Department of Biomedical Engineering at OHSU, the researchers analyzed amniotic fluid samples obtained from both human and non-human primates at different stages of gestation. They discovered that amniotic fluid plays a crucial role in regulating blood clotting through specific proteins and fatty acids that vary throughout pregnancy.
With the potential to diagnose and treat various prenatal conditions, the OHSU team is now working with Dr. Sanjay Malhotra to target disorders of pregnancy that could benefit from the protective properties of amniotic fluid. Additionally, they are collecting unique amniotic fluid samples from pregnancies undergoing in-utero repair surgeries for neural tube defects, such as spina bifida, to further understand its developmental elements and potential interventions.
The researchers are excited about the possibilities of harnessing the components of amniotic fluid to improve prenatal and maternal health. Dr. Brian Scottoline noted that a better understanding of amniotic fluid could lead to the development of new therapies for preterm babies, mimicking the protective properties of this fluid and aiding in their growth and development.
In conclusion, the study conducted by OHSU researchers sheds light on the protective properties of amniotic fluid and its potential therapeutic applications. By unraveling the mysteries of this vital substance, the team hopes to pave the way for innovative treatments that could significantly improve the health outcomes of both mothers and babies.
